If a test result does not impact management of a patient—or, worse, is misleading—should the test even be performed? Scrutiny about the guaiac-based fecal occult blood test and its role in the emergency department is long overdue. By carefully assessing this question, some hospitals have correctly concluded that it is time to retire fecal occult blood testing (FOBT).
The FOBT legend begins in the annals of screening for lower gastrointestinal malignancy. Small amounts of heme present in a stool sample react with a hydrogen peroxide–based developer to oxidize guaiac-infused paper, resulting in a blue color.1 Small amounts of blood, potentially from an otherwise asymptomatic early malignancy, may trigger appropriate downstream screening. Ultimately, population-based cancer screening using FOBT was popularized in the 1990s after several trials demonstrated mortality reductions.2 While we do not perform cancer screening in the emergency department, we may take an interest in the presence or absence of blood in the stool. Thus, this inexpensive, readily available test became part of the armamentarium of the emergency department.
Problems with FOBT
Unfortunately, guaiac-based FOBT is not a good test. When used for cancer screening, the sensitivity for malignancy—using heme positivity as a surrogate—is quite poor. Estimates for sensitivity of a single sample range from 15 to 30 percent.3 Because of these limitations, the typical collection procedure involves providing the patient with three separate cards upon which to collect samples from six different stools. These cumbersome procedures have coaxed the movement from guaiac-based kits toward immunochemical assays, whose sensitivity is sufficient with only one sample. Worse still with respect to ED practice, both sensitivity and specificity of guaiac-based FOBT for malignancy decrease with samples collected by digital rectal exam compared to those collected from spontaneously passed stool.4
Meanwhile, the list of sources of false-positive guaiac-based FOBT results is extensive. Nongastrointestinal blood, such as epistaxis, may produce a positive result unrelated to a clinically important etiology. Many foods can confound results of the guaiac-based FOBT, including meat products containing nonhuman heme and vegetables containing peroxidases, such as broccoli. When guaiac-based FOBT is used in outpatient screening, patients are instructed to abstain from such foods, which is not an option in the emergency department. The subjective nature of judging the color-based outcome on the card also leads to both false positives and false negatives.
These data do not generalize well to the emergency department. In the first place, the FOBT is designed to detect blood from an occult lower intestinal source rather than clinically important upper gastrointestinal bleeding. Understandably, as we are using this test outside its defined scope, we have little data with which to accurately describe its sensitivity and specificity. One small study evaluated three different stool tests for lower gastrointestinal bleeding in patients with anemia and known upper gastrointestinal lesions, and the guaiac-based test was positive in only 11 of 42 patients.5 The same study evaluated patients with quantities of ingested blood up to 15 mL; only one of 12 study subjects resulted a positive guaiac-based test. In a study evaluating 2,796 patients undergoing an immunochemical fecal blood test, a substantially more sensitive assay, the authors report advantages for detection of lower gastrointestinal tract lesions but no difference in presence of upper gastrointestinal lesions.6
With this excess of data throwing the utility of FOBT into question, the onus ought to be on those who would support its use in clinical settings to demonstrate its value. Hospitals that retrospectively evaluated the effect of guaiac-based FOBT on downstream testing have found profound mismatch between test results and follow-up endoscopy.7 This finding is consistent with surveys of the perceived value of the test across the spectrum of general practitioners as compared with gastroenterologists—a scant minority of gastroenterologists reported FOBT as appropriate for use in the emergency department, and the majority do not rely on the test to alter management.8
Eliminating the Test
In response, several hospitals have specifically removed the test either from use in the emergency department or the entire hospital.9,10 Parkland Hospital in Dallas, for example, retrospectively evaluated their practice patterns and identified FOBT as a low-value intervention used outside its appropriate scope. After a marginally successful initial attempt at reducing its use through educational interventions, the hospital simply eliminated the test. The discontinuation was led by the gastroenterology group, justifying their de-adoption by focused dissemination of cases in which the FOBT result had misled physicians. For example, there had been a colonic neoplasm thought to have been missed due to a false-negative FOBT collected by digital rectal examination. In many cases, unnecessary upper endoscopies were performed in response to false-positive results.
While a simple, sensitive, and specific test for upper gastrointestinal bleeding would certainly be of value, for want of such test, we should not mischaracterize and rely upon a poor one. It is absolutely time to retire—as my institution has—the guaiac-based FOBT from emergency department and inpatient use.
The opinions expressed herein are solely those of Dr. Radecki and do not necessarily reflect those of his employer or academic affiliates.
- Carroll MR, Seaman HE, Halloran HP. Tests and investigations for colorectal cancer screening. Clinl Biochem. 2014;47(10-11):921-939.
- Lieberman DA, Rex DK, Winawer SJ, et al. Guidelines for colonoscopy surveillance after screening and polypectomy: a consensus update by the US Multi-Society Task Force on Colorectal Cancer. Gastroenterology. 2012;143(3):844-857.
- Tinmouth J, Lansdorp-Vogelaar I, Allison JE. Faecal immunochemical tests versus guaiac faecal occult blood tests: what clinicians and colorectal cancer screening programme organisers need to know. Gut. 2015;64(8):1327-1337.
- Nakama H, Fattah AS, Zhang B, et al. Digital rectal examination sampling of stool is less predictive of significant colorectal pathology than stool passed spontaneously. Eur J Gastroenterol Hepatol. 2000;12(11):1235-1238.
- Harewood GC, McConnell JP, Harrington JJ, et al. Detection of occult upper gastrointestinal tract bleeding: performance differences in fecal occult blood tests. Mayo Clin Proc. 2002;77(1):23-28.
- Chiang TH, Lee YC, Tu CH, et al. Performance of the immunochemical fecal occult blood test in predicting lesions in the lower gastrointestinal tract. CMAJ. 2011;183(13):1474-1481.
- Sharma VK, Komanduri S, Nayyar S, et al. An audit of the utility of in-patient fecal occult blood testing. Am J Gastroenterol. 2001;96(4):1256-1260.
- Ip S, Sokoro AA, Buchel A, et al. Use of fecal occult blood test in hospitalized patients: survey of physicians practicing in a large central Canadian health region and Canadian gastroenterologists. Can J Gastroenterol. 2013;27(12):711-716.
- Cleveland NJ, Yaron M, Ginde AA. The effect of removal of point-of-care fecal occult blood testing on performance of digital rectal examinations in the emergency department. Ann Emerg Med. 2010;56(2):135-141.
- Gupta A, Tang Z, Agrawal D. Eliminating in-hospital fecal occult blood testing: our experience with disinvestment. Am J Med. 2018;131(7):760-763.