Dr. Chamorro noted that to change clinical practice, the findings would have to be confirmed in a pivotal trial. “In the meantime, uric acid is not available and it is not included in the current therapeutic guidelines of acute stroke. Overall, this manuscript stresses the urgency of replicating ASAP these very encouraging results,” he said.
In an email to Reuters Health, Dr. Larry Goldstein, a spokesperson for the American Stroke Association and codirector of the Kentucky Neuroscience Institute in Lexington, who was not involved with the study, said that while this analysis of a tertiary endpoint “does raise the possibility that combining uric acid with definitive clot removal (i.e., clot retrieval) might prove useful . . . this would need to be assessed in a prospective trial.”
The trial was funded by the Institute of Health Carlos III of the Spanish Ministry of Health, the Spanish Ministry of Economy and Competence, and the Fundacion Doctor Melchor Colet.
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