Logo

Log In Sign Up |  An official publication of: American College of Emergency Physicians
Navigation
  • Home
  • Multimedia
    • Podcasts
    • Videos
  • Clinical
    • Airway Managment
    • Case Reports
    • Critical Care
    • Guidelines
    • Imaging & Ultrasound
    • Pain & Palliative Care
    • Pediatrics
    • Resuscitation
    • Trauma & Injury
  • Resource Centers
    • mTBI Resource Center
  • Career
    • Practice Management
      • Benchmarking
      • Reimbursement & Coding
      • Care Team
      • Legal
      • Operations
      • Quality & Safety
    • Awards
    • Certification
    • Compensation
    • Early Career
    • Education
    • Leadership
    • Profiles
    • Retirement
    • Work-Life Balance
  • Columns
    • ACEP4U
    • Airway
    • Benchmarking
    • Brief19
    • By the Numbers
    • Coding Wizard
    • EM Cases
    • End of the Rainbow
    • Equity Equation
    • FACEPs in the Crowd
    • Forensic Facts
    • From the College
    • Images in EM
    • Kids Korner
    • Medicolegal Mind
    • Opinion
      • Break Room
      • New Spin
      • Pro-Con
    • Pearls From EM Literature
    • Policy Rx
    • Practice Changers
    • Problem Solvers
    • Residency Spotlight
    • Resident Voice
    • Skeptics’ Guide to Emergency Medicine
    • Sound Advice
    • Special OPs
    • Toxicology Q&A
    • WorldTravelERs
  • Resources
    • ACEP.org
    • ACEP Knowledge Quiz
    • Issue Archives
    • CME Now
    • Annual Scientific Assembly
      • ACEP14
      • ACEP15
      • ACEP16
      • ACEP17
      • ACEP18
      • ACEP19
    • Annals of Emergency Medicine
    • JACEP Open
    • Emergency Medicine Foundation
  • About
    • Our Mission
    • Medical Editor in Chief
    • Editorial Advisory Board
    • Awards
    • Authors
    • Article Submission
    • Contact Us
    • Advertise
    • Subscribe
    • Privacy Policy
    • Copyright Information

Johnson & Johnson Begins Ebola Vaccine Trials in Sierra Leone

By Ben Hirschler (Reuters) | on October 15, 2015 | 1 Comment
Latest News
  • Tweet
  • Click to email a link to a friend (Opens in new window) Email
Print-Friendly Version
Ebola

Johnson & Johnson (J&J) has begun a clinical trial of a two-shot Ebola vaccine in Sierra Leone, underlining its determination to push ahead with development, even as the epidemic fades out in West Africa.

You Might Also Like
  • Two-Part Ebola Vaccine Offers Long-Lasting Protection
  • Health Workers Rush to Contain Fresh Ebola Outbreak in Guinea
  • Ebola’s Persistence in Survivors Fuels Concerns Over Future Risks

The new study will investigate the experimental product’s safety and its ability to provoke an immune response to the disease, which the World Health Organization says has killed more than 11,000 people in Guinea, Liberia, and Sierra Leone.

Last week, for the first time since the Ebola outbreak was declared in March 2014, there were no new confirmed cases of the deadly disease in those countries, according to the U.N. agency.

Some survivors still suffer long-term effects from the virus, which can persist in parts of the body after clearing the blood, including a Scottish nurse taken ill in Sierra Leone last year who is now back in hospital for more treatment.

The world already has one successful Ebola vaccine, with Merck and NewLink Genetics’ product proving 100 percent effective in a clinical study in Guinea in July.

But scientists and drug companies are continuing to research the potential of alternatives, since different kinds of vaccines may be better suited for different population groups.

“Both regulators and governments around the world have encouraged us to continue,” Paul Stoffels, J&J’s chief scientific officer, told Reuters.

Campaign groups such as Medecins Sans Frontieres are also keen to see multiple manufacturers in order to have competition in the vaccine market to ensure lower prices and ample supply.

J&J, which is working with Bavarian Nordic in developing its vaccine, said that trial recruitment was underway in Sierra Leone and the first volunteers had received their initial vaccine dose.

This is the first study conducted of the so-called prime-boost vaccine regimen in a West African country affected by the recent Ebola epidemic.

J&J’s vaccine uses a combination of two components to strengthen the immunity and make it last longer. The U.S. healthcare company said it had scaled up production to more than 800,000 two-shot doses and had the capacity to produce 2 million if needed.

Scientific experts believe the success of Merck and NewLink’s vaccine suggests other products in trials should also prove effective.

Although these alternatives may not be tested in preventing Ebola cases, given the current lack of disease, they could still be licensed and readied for use in future outbreaks based on human immune response results and data from non-human primate experiments.

Pages: 1 2 | Single Page

Topics: AfricaEbolaResearchSierra LeoneVaccine

Related

  • October 2025 News from the College

    September 23, 2025 - 0 Comment
  • Reflecting on Four Decades at ACEP’s Council

    June 28, 2025 - 0 Comment
  • ACEP4U: Reinventing Research Education

    June 11, 2025 - 0 Comment

Current Issue

ACEP Now: November 2025

Download PDF

Read More

One Response to “Johnson & Johnson Begins Ebola Vaccine Trials in Sierra Leone”

  1. October 29, 2015

    Ebola's Persistence in Survivors Fuels Concerns Over Future Risks - ACEP Now Reply

    […] control. Partly because of the vast numbers involved in the epidemic, which centered on Guinea, Sierra Leone, and Liberia, infectious disease experts say we are learning more every day about Ebola from cases […]

Leave a Reply Cancel Reply

Your email address will not be published. Required fields are marked *


*
*


Current Issue

ACEP Now: November 2025

Download PDF

Read More

Polls

Which topic would you like to see ACEP Now tackle?

View Results

Loading ... Loading ...
  • Polls Archive
Wiley
  • Home
  • About Us
  • Contact Us
  • Privacy
  • Terms of Use
  • Advertise
  • Cookie Preferences
Copyright © 2025 by John Wiley & Sons, Inc. All rights reserved, including rights for text and data mining and training of artificial technologies or similar technologies. ISSN 2333-2603