Florida’s efforts to curb opioid abuse by registering pain clinics and electronically monitoring prescriptions may have helped reduce use of these narcotics, a study suggests.

To address so-called “pill mills,” or rogue pain management clinics where prescription opioids were being inappropriately prescribed or dispensed, Florida passed legislation in 2010 requiring the centers to register with the state and be owned by doctors. The state also established a prescription drug monitoring program (PDMP), which became operational in September 2011.

A year after both changes took effect, these policies were linked to a 1.4 percent decrease in opioid prescriptions, the researchers report online August 17 in JAMA Internal Medicine. Their calculations are based on the difference between actual pharmacy claims data and estimates of what would have happened without the law in place. “It’s possible over time that more substantial changes will be observed,” lead study author Lainie Rutkow, PhD, associate professor and researcher at Johns Hopkins Bloomberg School of Public Health, said by email.

The amount of prescription painkillers dispensed in the U.S. and related deaths quadrupled from 1999 to 2013, even though the number of Americans suffering from pain remained unchanged, according to the Centers for Disease Control and Prevention.
About a decade ago, Florida emerged as the epicenter of opiate misuse, addiction, and related deaths, with opioid-related surging 80 percent from 2003 to 2009, the researchers note. By 2010, 90 of the 100 U.S. physicians purchasing the highest amounts of oxycodone were in Florida.

To understand the impact of Florida’s “pill mill” law on opioid use in the state, researchers reviewed 480 million prescriptions from July 2010 to September 2012 in the state as well as in neighboring Georgia, which didn’t have a similar law.

Overall, about 8 percent of the prescriptions were for opioids. The database included records for 2.6 million patients, almost 432,000 prescribers and roughly 2,800 pharmacies. Over the study period, total opioid volume decreased 4 percent in Florida and 2.3 percent in Georgia, based on the weight of the prescribed drugs. Reductions were limited to prescribers and patients who had written or filled the highest volume of opioid prescriptions.

One limitation of the study is its reliance on retail pharmacies, which includes most but not all prescriptions, the researchers acknowledge. The study also couldn’t determine the separate effect of Florida’s policies regulating pill mills and tracking prescriptions because they took effect at about the same time. Nor did the study track whether the decrease in opioid prescriptions was linked to fewer overdoses or deaths.