Summary
Prochlorperazine (0.15 mg/kg) is the most commonly studied and most effective intravenous abortive migraine therapy in children. Combination therapy with ketorolac (0.5 mg/kg) appears to improve success. Plus-circle
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ACEP Now: Vol 40 – No 11 – November 2021References
- Brousseau DC, Duffy SJ, Anderson AC, et al. Treatment of pediatric migraine headaches: a randomized, double-blind trial of prochlorperazine versus ketorolac. Ann Emerg Med. 2004;43(2):256-262.
- Kannikeswaran N, Desai L, Farooqi A, et al. Effectiveness of standard combination therapy in pediatric migraine. Pediatric Neurol. 2021;116:68-73.
- Bachur RG, Monuteaux MC, Neuman MI. A comparison of acute treatment regimens for migraine in the emergency department. Pediatrics. 2015;135(2):232-238.
- Sheridan DC, Laurie A, Pacheco S, et al. Relative effectiveness of dopamine antagonists for pediatric migraine in the emergency department. Pediatr Emerg Care. 2018;34(3):165-168.
- Orr SL, Kabbouche MA, Horn PS, et al. Predictors of first-line treatment success in children and adolescents visiting and infusion center for acute migraine. Headache. 2018;58(8):1194-1202.
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