Conclusion
Febrile seizure recurrence in subsequent febrile illnesses does not appear to be affected by antipyretic usage. Newer literature in a high-incidence population—while only a single study—suggests that rectal acetaminophen may decrease recurrent febrile seizures during the same febrile illness.
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ACEP Now: Vol 39 – No 03 – March 2020References
- Offringa M, Newton R, Cozijnsen MA, et al. Prophylactic drug management for febrile seizures in children. Cochrane Database Syst Rev. 2017;2:CD003031.
- Rosenbloom E, Finkelstein T, Adams-Webber T, et al. Do antipyretics prevent the recurrence of febrile seizures in children? A systematic review of randomized controlled trials and meta-analysis. Eur J Paediatr Neurol. 2013;17(6):585-588.
- van Stuijvenberg M, Derksen-Lubsen G, Steyerberg EW, et al. Randomized, controlled trial of ibuprofen syrup administration during febrile illnesses to prevent febrile seizure recurrences. Pediatrics. 1998;102(5):E51.
- Strengell T, Uhari M, Tarkka R, et al. Antipyretic agents for preventing recurrences of febrile seizures: randomized controlled trial. Arch Pediatr Adolesc Med. 2009;163(9):799-804.
- Murata S, Okasora K, Tanabe T, et al. Acetaminophen and febrile seizure recurrences during the same fever episode. Pediatrics. 2018;142(5). pii:e20181009
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