References
- Hartnett KP, Kite-Powell A, DeVies J, et al. Impact of the COVID-19 pandemic on emergency department visits—United States, January 1, 2019–May 30, 2020. MMWR Morb Mortal Wkly Rep. 2020;69(23);699-704.
- Lau JYW, Yu Y, Tang RSY, et al. Timing of endoscopy for acute upper gastrointestinal bleeding. N Engl J Med. 2020;382(14):1299-1308.
- HALT-IT Trial Collaborators. Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. Lancet 2020;395:1927-1936.
- CRASH2 trial collaborators , Shakur H, Roberts I, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH2): a randomised, placebocontrolled trial. Lancet 2010;376 (9734):23-32.
- CRASH3 trial collaborators. Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH3): a randomised, placebocontrolled trial. Lancet. 2019;394 (10210):1713-1723.
- WOMAN Trial Collaborators. Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebocontrolled trial. Lancet 2017;389(10084):2105-2116.
Explore This Issue
ACEP Now: Vol 39 – No 09 – September 2020Pages: 1 2 3 | Single Page
2 Responses to “Two Studies Show When To Do an Endoscopy and Give Tranexamic Acid”
October 11, 2020
Micelle Jo HaydelIn HALT-IT, do the authors document home many patients were excluded because the physician chose to give TXA instead of enrolling ing the trial?
October 11, 2020
Ryan RadeckiHi Michelle –
I’m afraid they do not. The enrollment figure only reports how many were ultimately randomized, not how many they screened (or presented with UGIB). The supplementary appendix offers no further detail.
Excellent question.
– Ryan