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Liberate Methadone: An Introduction for the Emergency Medicine Physician

By Terence M. Hughes, MD; Joan Chen, MD; and Utsha G. Khatri, MD, MSHP | on April 14, 2025 | 0 Comment
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Dr. Chen is a resident at The Mount Sinai Hospital & Elmhurst Hospital Center.

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Dr. Khatri is an assistant professor of emergency medicine at the Icahn School of Medicine at Mount Sinai.

References

  1. Drug Overdose Deaths: Facts and Figures. NIDA. 2024 Aug1.
  2. Centers for Disease Control and Prevention. wisqars.cdc.gov/animated-leading-causes/2.
  3. Mattick RP, Breen C, Kimber J, Davoli M. Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence. Cochrane Database Syst Rev. 2009 Jul 8;(3):CD0022093.
  4. Larochelle MR, Bernson D, Land T, et al. Medication for Opioid Use Disorder After Nonfatal Opioid Overdose and Association With Mortality: A Cohort Study. Ann Intern Med. 2018 Jun 19;169:137-1454.
  5. Nguyen CMT, Kubiak G, Dixit N, Young SA, Hayes JR. Evaluating Barriers to Opioid Use Disorder Treatment From Patients’ Perspectives. PRiMER. 2024 Feb 19;8:115.
  6. Madras BK, Ahmad NJ, Wen J, Sharfstein J, et al. Improving Access to Evidence-Based Medical Treatment for Opioid Use Disorder: Strategies to Address Key Barriers Within the Treatment System. NAM Perspectives. 2020. Discussion Paper, Washington, DC6.
  7. Joudrey PJ, Edelman EJ, Wang EA. Drive Times to Opioid Treatment Programs in Urban and Rural Counties in 5 US States. JAMA. 2019 Oct 1;322(13):1310-13127.
  8. Substance Abuse and Mental Health Services Administration. Federal Guidelines for Opioid Treatment Programs. 2015 Mar8.
  9. Australian Government: Department of Health and Aged Care. National Guidelines for Medication-Assisted Treatment of Opioid Dependence. 2014 Apr9.
  10. Priest KC, Gorfinkel L, Klimas J, Jones AA, Fairbairn N, McCarty D. Comparing Canadian and United States opioid agonist therapy policies. Int J Drug Policy. 2019 Dec;74:257-26510.
  11. United Kingdom Department of Health and Social Care. Drug Misuse and Dependence: UK Guidelines on Clinical Management. 201711.
  12. Panwala V, Joudrey P, Kowalski M, Bach P, Amram O. Changes to methadone maintenance therapy in the United States, Canada, and Australia during the COVID-19 pandemic: A narrative review. J Subst Use Addict Treat. 2023 Sep;152:20908612.
  13. American Society of Addiction Medicine. Modernize it and Standardize It. 202513.
  14. Volkow N. Guest Editorial: To Address the Fentanyl Crisis, Greater Access to Methadone Is Needed. The ASAM Weekly. 202414.
  15. Markey EJ. S.644 – Modernizing Opioid Treatment Access Act. 202315.
  16. Davis J. Important Update on the “Three-Day” Rule for Administering Medications to Treat Opioid Use Disorder. ACEP. 2022 Apr16.
  17. National Coalition to Liberate Methadone, National Survivors Union, NYU Langone Center for Opioid Epidemiology and Policy (COEP). Liberating Methadone: A Roadmap for Change: Conference Proceedings and Recommendations. 2024 Jun17.

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