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Factor Xa Inhibitor Reversal Agent Is Not Ready for Prime Time

By Ryan Patrick Radecki, MD, MS | on May 2, 2019 | 0 Comment
Pearls From the Medical Literature
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ACEP Now: Vol 38 – No 04 – April 2019

The opinions expressed herein are solely those of Dr. Radecki and do not necessarily reflect those of his employer or academic affiliates.

References

  1. Pollack CV Jr, Reilly PA, van Ryn J, et al. Idarucizumab for dabigatran reversal – full cohort analysis. N Engl J Med. 2017;377(5):431-441.
  2. Connolly SJ, Crowther M, Eikelboom JW, et al. Full Study report of andexanet alfa for bleeding associated with factor Xa inhibitors (published online ahead of print Feb. 7, 2019). N Engl J Med. doi:10.1056/NEJMoa1814051.
  3. Frontera JA, Lewin JJ 3rd, Rabinstein AA, et al. Guideline for reversal of antithrombotics in intracranial hemorrhage: a statement for healthcare professionals from the Neurocritical Care Society and Society of Critical Care Medicine. Neurocrit Care. 2016;24(1):6-46.
  4. Andexxa— an antidote for apixaban and rivaroxaban. Med Lett Drugs Ther. 2018;60(1549):99-101.
  5. Lu G, Lin JP, Curnutte JT, et al. Effect of andexanet-TFPI interaction on in vitro thrombin formation and coagulation markers in the TF-pathway. Blood. 2017;130(Suppl. 1):629.
  6. Ansell JE, Bakhru SH, Laulicht BE, et al. Single-dose ciraparantag safely and completely reverses anticoagulant effects of edoxaban. Thromb Haemost. 2017;117(2):238-245.

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Topics: CMECME Now

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About the Author

Ryan Patrick Radecki, MD, MS

Ryan Patrick Radecki, MD, MS, is an emergency physician and informatician with Christchurch Hospital in Christchurch, New Zealand. He is the Annals of Emergency Medicine podcast co-host and Journal Club editor and can be found on Twitter @emlitofnote.

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