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Demonic Possession or Autoantibody-Mediated Encephalitis?

By Ryan Patrick Radecki, MD, MS | on June 19, 2019 | 3 Comments
Pearls From the Medical Literature
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References

  1. Cahalan S. Brain on Fire: My Month of Madness. New York: Simon & Schuster; 2012.
  2. Carr D. Turning a zebra into a horse. Presented at: Social Media and Critical Care Conference, March 2019; Sydney, Australia.
  3. Jammoul A, Li Y, Rae-Grant A. Autoantibody-mediated encephalitis: not just paraneoplastic, not just limbic, and not untreatable. Cleve Clin J Med. 2016;83(1):43-53.
  4. Binks SNM, Klein CJ, Waters P, et al. LGI1, CASPR2 and related antibodies: a molecular evolution of the phenotypes. J Neurol Neurosurg Psychiatry. 2018;89(5):526-534.
  5. Graus F, Titulaer MJ, Balu R, et al. A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 2016;15(4):391-404.
  6. Dubey D, Pittock SJ, Kelly CR, et al. Autoimmune encephalitis epidemiology and a comparison to infectious encephalitis. Ann Neurol. 2018;83(1):166-177.

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Explore This Issue
ACEP Now: Vol 38 – No 06 – June 2019

Pages: 1 2 | Single Page

Topics: autoantibody-mediated encephalitisDeliriumDementiaencephalitisinsanity

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About the Author

Ryan Patrick Radecki, MD, MS

Ryan Patrick Radecki, MD, MS, is an emergency physician and informatician with Christchurch Hospital in Christchurch, New Zealand. He is the Annals of Emergency Medicine podcast co-host and Journal Club editor and can be found on Twitter @emlitofnote.

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3 Responses to “Demonic Possession or Autoantibody-Mediated Encephalitis?”

  1. May 25, 2020

    Julia Reply

    Fascinating. Could seemingly demonic possession be attributed to any subtype of encephalitis or does it generally relate to Seronegative Limbic Encephalitis, Non-Paraneoplastic Limbic Encephalitis, and Typical/Atypical Limbic Encephalitis?

  2. May 28, 2020

    Ryan Radecki Reply

    To my knowledge, it pertains specifically to these NMDA receptor antibodies – and produces the clinical syndromes associated with other hallucinogenic pharmacology (e.g., Ibotenic acid in Amanita mushrooms).

  3. August 5, 2025

    Phil Reply

    But, then, you have cases like this:
    https://www.indystar.com/story/news/2014/01/25/the-disposession-of-latoya-ammons/4892553/
    Exorcists tend to want psychological and psychiatric conditions ruled out, but, even after that, you still have phenomrna that defy the natural. I doubt even the ability to unlock all your brain’s potential could allow a person to walk up a hospital wall, as witnessed by a nurse and case manager.

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