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A Practical Guide to Diagnosing Delirium and Acute Cognitive Change in the ED

By Sonja Foo, MBBS | on December 23, 2025 | 0 Comment
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Delirium isn’t a harmless observation — it’s a red flag of serious underlying pathology. And although encephalopathy may underlie it, naming the process isn’t enough. Treat delirium as a syndrome that demands the question: What prompted this and what can we do about it? Use 4AT. Use structured frameworks. Document thoroughly. Protect patients and your practice.

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ACEP Now: January 2026

Let’s stop calling it “confusion.” Let’s start recognizing it as what it might be — delirium — and manage it accordingly. Our patients deserve nothing less.


Dr. Sonja Foo is a board-certified emergency medicine critical care physician completing her Neurocritical Care Fellowship at the Massachusetts General Hospital, Brigham and Women’s Hospital, and Harvard Medical School Training Program.

 

References

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  4. Lee JS, Tong T, Chignell M, et al. Prevalence, management and outcomes of unrecognized delirium in a national sample of 1,493 older emergency department patients: how many were sent home and what happened to them? Age Ageing. 2022;51(2):afab214.
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  7. Shenkin SD, Fox C, Godfrey M, et al. Protocol for validation of the 4AT, a rapid screening tool for delirium: a multicentre prospective diagnostic test accuracy study. BMJ Open. 2018;8(2):e015572.
  8. Tieges Z, Maclullich AMJ, Anand A, et al. Diagnostic accuracy of the 4AT for delirium detection in older adults: systematic review and meta-analysis. Age Ageing. 2021;50(3):733-743.
  9. Jeong E, Park J, Lee J. Diagnostic test accuracy of the 4AT for delirium detection: a systematic review and meta-analysis. Int J Environ Res Public Health. 2020;17(20):7515.
  10. Shenkin SD, Fox C, Godfrey M, et al. Delirium detection in older acute medical inpatients: a multicentre prospective comparative diagnostic test accuracy study of the 4AT and the confusion assessment method. BMC Med. 2019;17(1):138.
  11. Thomas J, Moore G. Medical-legal Issues in the agitated patient: cases and caveats. West J Emerg Med. 2013;14(5):559-65.
  12. Reeves RR, Pinkofsky HB, Stevens L. Medicolegal errors in the ED related to the involuntary confinement of psychiatric patients. Am J Emerg Med. 1998;16(7):631-3.
  13. Barstow C, Shahan B, Roberts M. Evaluating medical decision-making capacity in practice. Am Fam Physician. 2018;98(1):40-46.
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  15. Ghaith S, Moore GP, Colbenson KM, Lindor RA. charting practices to protect against malpractice: case reviews and learning points. West J Emerg Med. 2022;23(3):412-417.

Pages: 1 2 3 4 | Single Page

Topics: acute cognitive changeDeliriumencephalopathyGeriatric

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