Coagulation factor concentrates (CFC) are more effective than fresh frozen plasma (FFP) for reversing trauma-induced coagulopathy, according to a new randomized trial.
“Our results underline the importance of early fibrinogen supplementation for severe clotting failure in multiple trauma,” Dr. Petra Innerhofer of the Medical University of Innsbruck in Austria and colleagues write. “A CFC-based algorithm guided by viscoelastic tests is considerably superior to FFP transfusion.”
There has been “great uncertainty” about whether FFP or CFC, or a combination of the two, should be used to treat trauma-induced coagulopathy, Dr. Innerhofer and her colleagues note in their report, published online April 28 in The Lancet Haematology.
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