The absolute risk increase is, indeed, quite small—particularly for younger patients. As the risks grow, however, it is reasonable to consider these adverse effects, along with the potential harms of alternative therapies, in the context of the expected magnitude of benefit. Even if the risk to an individual patient may be low, the cumulative effect of this practice will ultimately have population-level costs and harms to be weighed against the societal and personal costs of self-limited symptomatology.
– Ryan P. Radecki, MD, MS, FACEP
Portland, Oregon
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