We’ve all seen this patient: past medical history of congestive heart failure (CHF) and creatinine of 5.6 who presents in septic shock. The much-discussed SEP-1 quality metric mandates an intravenous fluid bolus (30 ml/kg), but clinicians fear causing pulmonary edema, leading to a need for intubation. These two abstracts look at institutional databases and found that even in patients with CHF and end-stage renal disease (ESRD), following SEP-1 decreased mortality. Furthermore, there was no increase in intubation in septic patients with CHF and ESRD when clinicians followed SEP-1.
Explore This IssueACEP Now: Vol 37 – No 04 – April 2018
While noting, once again, the caveat of observational data and likely inclusion bias, this still provides some reassurance to providers caring for septic patients with CHF or ESRD.
A Randomized Study of Naproxen Plus Placebo, Orphenadrine, or Methocarbamol for Acute Low Back Pain
Friedman BW, Irizarry, E, Solorzano, C, et al
Back pain continues to be a common reason for ED visits, and Dr. Friedman and colleagues continue to search for effective treatments. This double-blind trial randomized patients to receive naproxen plus a one-week supply of either orphenadrine (Norflex) 100mg, methocarbamol (Robaxin) 750mg, or placebo. Unfortunately, 34 percent of naproxen+placebo patients reported moderate or severe low back pain versus 33 percent of naproxen+orphenadrine and 39 percent of naproxen+ methocarbamol patients. This study reinforces an approach that emphasizes nonsteroidal anti-inflammatory drugs and education for patients with musculoskeletal back pain.
Do Intranasal Vasoconstrictors Increase Blood Pressure?
Bellew SD, Johnson KL, Kummer T
This study calls to mind another common ED scenario: the epistaxis patient with severe hypertension. In this elegant randomized, double-blinded, placebo-controlled trial, a convenience sample of patients was assigned to one of four arms: phenylephrine 0.25%, oxymetazoline 0.05%, lidocaine 1% with epinephrine 1:100,000, or bacteriostatic 0.9% sodium chloride in cotton soaked nasal pledgets. They did not find any changes in blood pressure over the 30 minutes after drug administration between any of the arms. This suggests that vasoconstrictors cause minimal acute blood pressure changes when applied nasally via soaked pledgets.
High Sensitivity Troponin T (hsTnT) Identifies Patients at Very Low Risk of Adverse Events
Peacock WF, Baumann B.M, Bruton D, et al
There has been much literature published on the utility of high-sensitivity troponin assays. This study reports on their use in an American cohort. This Roche-funded study examined a three-hour protocol in 1,264 ED patients suspected of having acute coronary syndrome, finding that in the 974 (77.1 percent) patients with both a zero- and three-hour hsTnT<19 ng/L a 30-day adverse cardiac event occurred in seven patients for a negative predictive value of 99.3 percent (95 percent CI, 99.05–99.55).
Telehealth for Low-acuity EMS: One Fire-based System Experience with 10,000 Patients
Gonzalez MG, Persse DE, Gleisberg GR, et al
Telemedicine in the Emergency Department: A Novel, Academic Approach to Optimizing Operational Metrics and Patient Experience
Sharma R, Clark S, Torres-Lavoro J, et al