Editor’s Note: This is the third part of an ongoing series on what emergency physicians can do to combat the opioid epidemic. The series will continue in the August issue.
I feel cheated! After all that time in pharmacology classes and the tests in undergraduate, graduate school, medical school, and residency all oversimplify the concept of the difference between a partial agonist and full agonist. When you dig deep into the pharmacology literature, you find only one true full agonist, DAMGO (ie, [D-Ala2, N-MePhe4, Gly-ol]-enkephalin), which is not even a medication used in humans.